Omeprazole is rapidly absorbed from the gastrointestinal tract, the maximum concentration achieved in the plasma at 0.5 – 1 hour. Bioavailability is 30 – 40%.Communication with plasma proteins – about 90%. Omeprazole is almost completely metabolized in the liver. It is an inhibitor of tren 100 side effects enzyme system. The half – 0.5-1 hour. Report the news (about 70-80%) and the bile (20-30%). In chronic renal insufficiency excretion is reduced in proportion to the decrease in creatinine clearance. In elderly patients deducing decreases, bioavailability increases. In liver failure bioavailability – 100%, half-life – 3 h.
- Gastric ulcer and duodenal ulcer (in the acute phase and protivoretsedivnoe treated), including associated with Helycobacter pylori (in the complex therapy);
- Reflux esophagitis;
- Erosive-ulcerative lesions of gastric and duodenal ulcers associated with nonsteroidal anti-inflammatory preparty (NSAIDs);
- Zollinger-Ellison Syndrome.Contraindications:
Hypersensitivity to the drug, children’s age, the period of lactation.
renal and / or hepatic impairment.
Use during pregnancy
Use of omeprazole during pregnancy possible in cases where the expected benefit to the mother outweighs the potential risk to the fetus.
Dosing and Administration
Inside, squeezed a small amount of water (the contents of the capsule should not be chewed). Duodenal ulcer exacerbation – 20 mg daily for 2-4 weeks (in resistant cases up to 40 mg per day). Peptic ulcer exacerbation and erosive and ulcerative esophagitis – on 20-40 mg daily for 4-8 weeks. erosive and ulcerative lesions of the gastrointestinal tract caused by NSAID – 20 mg daily for 4-8 weeks. Eradication of Helicobacter pylori – on 20 mg 2 times a day for 7 or 14 days (depending on the applied regimen) in combination with antibacterial agents. anti-treatment of gastric ulcer and 12 duodenal ulcer -. 20 mg a dayof anti-treatment of reflux esophagitis – 20 mg per day for long periods (up to 6 months). Receiving the request (symptomatic treatment). Zollinger-Ellison Syndrome – dose selected tren 100 side effects individually depending on the initial level of gastric secretions, typically from 60 mg per day. If necessary, increase the dose to 80 -. 120 mg per day, in this case, it is divided into 2 doses in patients with severe hepatic insufficiency daily dose should not exceed 20 mg.
In rare cases, there may be the following, usually reversible side effects: On the part of the digestive system: diarrhea or constipation, nausea, vomiting, flatulence, abdominal pain, dry mouth, taste disturbances, stomatitis, transient increase in activity of “liver” enzymes plasma; in patients with previous severe liver disease – hepatitis (including jaundice..), abnormal liver function. From the nervous system: headache, dizziness, agitation, drowsiness, insomnia, paresthesias, depression, hallucinations; in patients with severe concomitant somatic diseases, patients with liver disease previous heavy – encephalopathy. From the musculoskeletal system: muscle weakness, myalgia, arthralgia. Hematopoietic system: leukopenia, thrombocytopenia; . in some cases – agranulocytosis, pancytopenia For the skin: itching, skin rash; in some cases -fotosensibilizatsiya, erythema multiforme, alopecia. Allergic reactions: urticaria, angionevrichesky edema, bronchospasm, interstitial nephritis, anaphylactic shock, fever. Other: visual disturbances, peripheral edema, increased sweating, gynecomastia; seldom – formation of gastric glandular cysts during long-term treatment (a consequence of inhibiting the secretion of hydrochloric acid, is benign, reversible).
is a symptom of omeprazole overdose: blurred vision, drowsiness, agitation, confusion, headache, increased sweating, dry mouth, nausea, arrhythmia.
Specific antidote does not exist. Treatment is symptomatic. Hemodialysis – not sufficiently effective.
The interaction with other drugs
Prolonged use of omeprazole 20 mg 1 time per day in combination with caffeine, theophylline, piroxicam, diclofenac, naproxen, metoprolol, propranolol, ethanol, cyclosporine, lidocaine, quinidine and estradiol did not change concentration in plasma .
There was no interaction with simultaneously take an antacid. It may reduce the absorption of ampicillin esters, iron salts, itraconazole and ketoconazole (omeprazole increases gastric pH). As an inhibitor of cytochrome P450, may increase the concentration and reduce the excretion of diazepam indirect anticoagulants, phenytoin (drugs that are metabolized in the liver by cytochrome CYP2C19), which in some cases may require reducing the dose of these drugs. It enhances inhibitory action on other hemopoietic system drugs.
Before treatment to rule out tren 100 side effects the presence of malignant process (especially gastric ulcer), as treatment, masking symptoms, may delay correct diagnosis.
The reception at the same time with food does not affect its efficiency.
If you have trouble swallowing whole capsules can be swallowed its contents after opening or sucking the capsule and can mix the contents of the capsule with a slightly acidic liquid ( juice, yogurt), and use the resulting suspension for 30 min.
The normal dosage formulation has no effect on psychomotor reactions rate and concentration.
Running low dose t3 clen cycle trying to lose bodyfat isn’t a real hot idea imo.