Trenbolone hexahydrobenzylcarbonateat the level of plasma protein binding (increases the concentration of drugs competing for the connection with plasma proteins).
The action of medicines which reduce blood clotting, increases with their simultaneous use with nimesulide.
Nimesulide can reduce the effect of furosemide.
Hepatotoxic drugs -. increased risk of hepatotoxic action
of lithium plasma levels increased while taking drugs nimesulide and lithium.
nimesulide may increase the possibility of occurrence of side effects while taking methotrexate.
Because of the high degree of binding of nimesulide to plasma proteins patients who simultaneously treat hydantoin and sulfonamides should be under a doctor’s supervision, undergoing tests at short intervals.
Nimesulide may increase the effects of cyclosporin on the kidney.
caution should be exercised with simultaneous use of the drug with other NSAIDs, digoxin, phenytoin, antihypertensive agents, theophylline, anti-diabetic agents.
should use the minimum effective dose as low as possible short course. To reduce the risk of adverse effects from the gastrointestinal tract
is not recommended long-term use of the drug, as well as the co-administration with other nonsteroidal anti-inflammatory drugs.
With extreme caution should be used nimesulide in hypertension, heart failure, and diabetes mellitus (type II).
The caution and in low doses prescribed nimesulide when expressed violations of liver and kidney function in disorders of the gastrointestinal tract (peptic ulcer, bleeding, ulcerative colitis), while the use of diuretics, anticoagulants and elderly. Since nimesulide is partially excreted by the kidneys, its dosage for patients with impaired renal function should be reduced, depending on the level of urine.
Prolonged use of a systematic monitoring of renal function. Patients should undergo regular medical supervision if they take along with nimesulide medicines, which are characterized by the effect on the gastrointestinal tract.
Avoid co-administration with hepatotoxic drugs, and alcohol. Taking into account the reports of violations of patients taking other nonsteroidal: anti-inflammatory drugs, treatment should be stopped immediately if there is any violation of, and the patient should be examined by a doctor-ophthalmologist.
If signs of hepatotoxicity (itchy skin, yellowing of the skin, nausea,. vomiting, abdominal pain, dark urine, increased activity of “liver” transaminases) should stop taking trenbolone hexahydrobenzylcarbonate the drug.
Using the drug for more than 2 weeks is necessary to monitor liver function tests (transaminases).
Nimesulide can change the properties of platelets, but does not replace the prophylactic effect of acetylsalicylic acid at cardiovascular diseases.
The use of nimesulide may adversely affect female fertility and is not recommended for women planning pregnancy.
In some patients the drug can cause dizziness or drowsiness. Therefore, patients taking nimesulide should be limited to activities related to the need for rapid response and high concentration.
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