Drug from the group of aliphatic derivatives of phenothiazine. The chemical structure and activity spectrum propazina similar to what is tren but the drug is less active and less toxic.
The mechanism of action of antipsychotic propazina associated with blocking postsynaptic mesolimbic dopaminergic receptors in the brain.
By the force of the antipsychotic and sedative effect inferior aminazinu; reduces motor activity, has antiemetic, anti-hypertensive and gipogermicheskoe action. It has less severe side effects (effects of akathisia, confusion, depression, lethargy, apathy, extrapyramidal disorder somatovegetativnye n) than chlorpromazine. It increases the duration and intensity of the action of hypnotics, narcotics, analgesics, antihypertensives, antihistamines and alcohol.
Well absorbed after oral administration. The time to reach maximum concentration of 2-4 hours. Communication with plasma proteins – 90%. It is metabolized in the liver to inactive metabolites. Shown mainly kidneys.
Acute and chronic psychosis, accompanied by psychomotor excitation, hallucinatory and delusional disorders , mania, anketirovannye depression, psychotic disorders of any etiology; in other psychiatric diseases (neurosis, psychopathy, reactive states), accompanied by excitement, fear, insomnia, stress, impulsive attacks, to relieve withdrawal symptoms in drug treatment practice.
Propazin can be used in conjunction with other psychotropic drugs (antidepressants, derivatives of butyrophenone and others. .)
as with vomiting antiemetic various etiologies.
- increased individual sensitivity;
- CNS depression and coma function of any etiology;
- brain injury;
- liver disease, kidney and blood-forming organs in violation of the functions;
- progressive system of the brain and spinal cord diseases;
- gastric ulcer and 12 duodenal ulcer during the exacerbation;
- heart disease in the stage of decompensation (heart disease, myocardial dystrophy, rheumatic heart disease, etc.), severe hypotension, diseases accompanied by the risk of thromboembolic complications;
- bronchiectasis in the stage of decompensation;
- angle-closure glaucoma (risk of increased intraocular pressure);
- prostatic what is tren hyperplasia;
- pregnancy, breast-feeding;
- children under 12 years.
Dosing and Administration
Propazin are inside (after eating).
Inside appoint 25 – 100 mg 2-4 times a day, if necessary dose gradually increased to 500-1000 mg / day. For maintenance therapy appoint 50 – 150 mg 1-2 times a day.
Children 12 years and older: the interior of 25 mg every 4-6 hours, if necessary and taking into account the tolerance dose is adjusted.
What is tren better tolerated than chlorpromazine, and less likely to cause side effects, but with a long reception of the drug, the following effects:
As correctors used antiparkinsonian agents – tropatsin, Trihexyphenidyl, etc. Dyskinesia (paroxysmal occurring seizures neck muscles, tongue, floor of the mouth, okologirnye crises) -. Cropped caffeine-sodium benzoate (2 ml of a 20% solution subcutaneously) and atropine (1 ml 0 1% solution subcutaneously).
Perhaps the development of tardive dyskinesia, at least -. neuroleptic malignant syndrome
early treatment may experience drowsiness, dizziness, dry mouth, nasal congestion, anorexia, accommodation disturbances (blurred vision), moderately severe orthostatic hypotension, tachycardia, sleep disorders, difficulty urinating, nausea, vomiting, gastralgia, constipation.
Rare complications are pigmentary retinopathy, cholestatic jaundice, cardiac arrhythmia, leukopenia, agranulocytosis, allergic skin reactions, angioedema, menstrual irregularities, decreased sexual potency, galactorrhea, priapism, melanosis, violation of thermoregulation (heat stroke), weight gain.
There may be allergic reactions of the skin and mucous membranes: swelling of the face, extremities, and skin photosensitivity (patients should not therefore be exposed to UV radiation).
in applying propazin can psychic phenomena occur indifference, a belated reaction to external stimuli, and other mental changes.
Overdose (intoxication) drug Symptoms : areflexia and hyperreflexia, blurred vision, cardiotoxic effects (arrhythmia, heart failure, decreased blood pressure, shock, tachycardia, changes in wave the QRS, ventricular fibrillation, cardiac arrest), neurotoxic effects, including agitation, confusion, convulsions, disorientation, lethargy, stupor or coma; dilated pupils, dry mouth, hyperpyrexia or hypothermia, muscle rigidity, vomiting, pulmonary edema and respiratory depression. Treatment: gastric lavage, the appointment of activated charcoal (to avoid the induction of vomiting as impaired consciousness, and dystonic reactions from the muscles of the neck and the head, caused by an overdose may what is tren lead to aspiration of vomit). Symptomatic treatment : arrhythmia – in / phenytoin 9-11 mg / kg, in heart failure – cardiac glycosides, with marked decrease in blood pressure – in / in a liquid or vasopressor agents such as norepinephrine, phenylephrine (avoid the use of alpha- and beta-agonists such as epinephrine), in convulsions – diazepam, parkinsonism – difeniltropin, diphenhydramine. Control functions of the cardiovascular system during at least 5 days, the central nervous system, respiration, body temperature measurement, psychiatric counseling. Dialysis is ineffective.
Interaction with other drugs
With simultaneous application propazin with other drugs, have a depressing effect on the central nervous system (means of anesthesia, narcotic analgesics, alcohol and containing his medications, barbiturates, tranquilizers, and others.) May increase CNS depression as well as respiratory depression,
with tricyclic antidepressants, maprotiline, or MAO inhibitors – increase the risk of neuroleptic malignant syndrome;
with anticonvulsants – may decrease the seizure threshold,
with preparations for the treatment of hyperthyroidism – increased risk of agranulocytosis;
with other drugs that cause extrapyramidal reactions – may increase the frequency and severity of extrapyramidal disorders ;
with antihypertensive drugs – possible orthostatic hypotension
with ephedrine – possibly weakening vasoconstrictor ephedrine effect,
reduces the effectiveness of the emetic action of apomorphine enhances its inhibitory effect on the central nervous system,
reduces the effect of resources, reducing appetite (except for fenfluramine);
– simultaneous application of bromocriptine may increase in plasma concentrations of prolactin and to reduce its effects.
in the treatment propazine avoid administration of epinephrine (adrenaline), since distortion may effect epinephrine, which can lead to a drop in blood pressure. Antiparkinsonian effect of levodopa is reduced due to the blocking of dopamine receptors. Propazin can suppress the effect of amphetamines, clonidine, guanethidine.
Propazin enhances anticholinergic effects of other drugs, and the antipsychotic effect of neuroleptics may be reduced.
In an application propazin with a related chemical structure prochlorperazine may come a prolonged loss of consciousness.
It is necessary to avoid the simultaneous use with absorbent and antidiarrheal agents . Suction propazin broken, while the use of antacids, antiparkinsonian agents, drugs lithium.